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Publications

First Author Peer Reviewed Original Research Papers:

  1. Chi C, Loy SL, Chan SY, Choong C, Cai S, Soh SE, Tan KH, Yap F, Gluckman PD, Godfrey KM, Shek LP, Chan JKY, Kramer MS, Chong YS. Impact of adopting the 2013 World Health Organization criteria for diagnosis of gestational diabetes in a multi-ethnic Asian cohort: a prospective study. BMC Pregnancy Childbirth. 2018 Mar 21; 18(1): 69.
  2. Chi C, Pang D, Aris IM, Teo WT, Li SW, Biswas A, Yong EL, Chong YS, Tan K, Kramer MS. Trends and predictors of cesarean birth in Singapore, 2005-2014: A population-based cohort study. Birth. 2018 Feb 17. (Epub ahead of print)
  3. Chi C, FY Huq, Kadir RA. Levonorgestrel-releasing intrauterine system for the management of heavy menstrual bleeding in women with inherited bleeding disorders: Long term follow-up. Contraception 2011; 83(3): 242-7.
  4. Chi C, Pollard D, Tuddenham ED, Kadir RA. Menorrhagia in adolescents with inherited bleeding disorders. Journal of Pediatric and Adolescent Gynecology 2010; 23(4): 215-22.
  5. Chi C, Bapir M, Lee CA, Kadir RA. Puerperal loss (lochia) in women with or without inherited bleeding disorders. American Journal Obstetrics and Gynecology 2010; 203(1): 56.e1-5.
  6. Chi C, Kulkarni A, Lee CA, Kadir RA. The obstetric experience of women with factor XI deficiency. Acta Obstet Gynecol Scand 2009; 88(10): 1095-1100.
  7. Chi C, Lee CA, England A, Hingorani J, Paintsil J, Kadir RA. Obstetric analgesia and anaesthesia in women with inherited bleeding disorders. Thrombosis and Haemosatsis 2009; 101: 1104-1111.
  8. Chi C, Lee CA, Shiltagh N, Khan A, Pollard D, Kadir RA. Pregnancy in carriers of haemophilia. Haemophilia 2008; 14: 56-64.
  9. Chi C, Shiltagh N, Kingman CEC, Economides DL, Lee CA, Kadir RA. Identification and management of women with inherited bleeding disorder: A survey of obstetrician and gynaecologists in the United Kingdom. Haemophilia 2006; 12: 405-412.
  10. Chi C, Hyett JA, Finning KM, Lee CA, Kadir RA. Non-invasive first trimester determination of fetal gender: A new approach for prenatal diagnosis of haemophilia. BJOG 2006; 113: 239-242.

Other Peer Reviewed Original Papers:

  1. Loy SL, Cheung YB, Soh SE, Ng S, Tint MT, Aris IM, Bernard JY, Chong YS, Godfrey KM, Shek LPC, Tan KH, Lee YS, Tan HH, Chern BSM, Lek N, Yap F, Chan SY, Chi C, Chan JKY. Female adiposity and time-to-pregnancy: a multi-ethnic prospective cohort. Human Reproduction 2018 In Press
  2. Hew Hewage SS, Singh SR, Chi C, Chan JKY, Yew TW, Han WM, Yoong J. Health Care Providers' Perceptions of Responsibilities and Resources to Reduce Type 2 Diabetes Risk After Gestational Diabetes Mellitus. Clin Diabetes. 2018 Apr; 36(2): 160-167.
  3. Lau Y, Cheng LJ, Chi C, Tsai C, Ong KW, Ho-Lim SST, Wang W, Tan KL. Development of a Healthy Lifestyle Mobile App for Overweight Pregnant Women: Qualitative Study. JMIR Mhealth Uhealth. 2018 Apr 23; 6(4): e91.
  4. Lau Y, Klainin-Yobas P, Htun TP, Wong SN, Tan KL, Ho-Lim ST, Chi C, Tsai C, Ong KW, Shorey S, Tam WSW. Electronic-based lifestyle interventions in overweight or obese perinatal women: a systematic review and meta-analysis. Obes Rev. 2017 Sep;18(9):1071-1087.
  5. Lau Y, Htun TP, Lim PI, Ho-Lim SS, Chi C, Tsai C, Ong KW, Klainin-Yobas P. Breastfeeding attitude, health-related quality of life and maternal obesity among multi-ethnic pregnant women: A multi-group structural equation approach. Int J Nurs Stud. 2017 Feb; 67: 71-82.
  6. Teng JY, Yin Ing Chee C, Chong YS, Lee le Y, Yong EL, Chi C, Broekman B. A suicidal pregnant patient's request for premature Cesarean section: Clinical and ethical challenges. J Affect Disord. 2016 Apr; 194: 168-70.
  7. Tsui NB, Kadir RA, Chan KC, Chi C, Mellars G, Tuddenham EG, Leung TY, Lau TK, Chiu RW, Lo YM. Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA. Blood 2011; 117 (13): 3684-91.
  8. Kadir RA, Kingman CEC, Chi C, Lee CA, Riddell A, Economides DL. Is primary postpartum haemorrhage a good predictor of inherited bleeding disorders? Haemophilia 2007: 13: 178-181.
  9. Kadir RA, Kingman CEC, Chi C, O’Connell NM, Riddell A, Lee CA, Economides DL. Screening for factor XI deficiency amongst pregnant women of Ashkenazi Jewish origin. Haemophilia 2006; 12: 625-628.

Review Articles:

  1. den Ruijter H, Pasterkamp G, Rutten FH, Lam CS, Chi C, Tan KH, van Zonneveld AJ, Spaanderman M, de Kleijn DP. Heart failure with preserved ejection fraction in women: the Dutch Queen of Hearts program. Neth Heart J. 2015 Feb; 23(2): 89-93.
  2. Chi C, Kadir RA. Inherited bleeding disorders in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2012 Feb; 26 (1): 103 – 117.
  3. Kadir RA, Chi C, Bolton-Maggs PHB. Pregnancy and Rare bleeding disorders. Haemophilia 2009; 15(5): 990-1005.
  4. Lee CA, Chi C, Shiltagh N, Pollard D, Griffioen A, Dunn N, Kadir RA. Review of a multidisciplinary clinic for women with inherited bleeding disorders. Haemophilia 2009; 15(1): 359-60.
  5. Burton C, Chi C, Kadir RA. Gynaecological problems and choices for contraception in women with inherited bleeding disorders. Journal of Family Planning and Reproductive Health Care 2008; 34(2): 93-98.
  6. Shankar M, Chi C, Kadir RA. Review of quality of life: menorrhagia in women with or without inherited bleeding disorders. Haemophilia 2008; 14: 15-20.
  7. Kadir RA, Chi C. Levonorgestrel intrauterine system: Bleeding disorders and anticoagulant therapy. Contraception 2007; 75 (6Suppl): S123-9.
  8. Chi C, Kadir RA. Management of women with inherited bleeding disorders in pregnancy. The Obstetrician and Gynaecologist 2007; 9: 27-33.
  9. Kadir RA, Chi C. Women and von Willebrand Disease: Controversies in diagnosis and management. Seminar in Thrombosis Hemostasis 2006; 32: 605-615.

Letter / Editorials:

  1. Chi C, Lee CA, Kadir RA. Women Bleed Too. Acta Obstet Gynecol Scand 2007; 86(7): 772-3.
  2. Chong YS, Chi C, Holbrook JD. Genetic contribution to postpartum haemorrhage. BMJ 2014 Aug 27; 349: g5285.

Case Reports:

  1. Ogutu D, Anastasakis E, Chi C, Kadir RA. First trimester diagnosis of conjoint (pygopagus) twins: A case report of successful prenatal and postnatal management. J Obstet Gynaecol. 2008; 28(3): 340-2.
  2. Chi C, Taylor A, Munjuluri, Kadir RA. A diagnostic dilemma: round ligament varicosities in pregnancy. Acta Obstet Gynecol Scand 2005; 84: 1126-1127.

Peer Reviewed National Guidelines:

  1. Lee CA, Chi C, Pavord SR, Bolton-Maggs PHB, Pollard D, Hinchcliffe-Wood A, Kadir RA. The obstetric and gynaecological management of women with inherited bleeding disorders – review with guidelines produced by a taskforce of UK Haemophilia Centre Doctors’ Organization. Haemophilia 2006; 12: 301-336.

Book Chapters:

  1. Chi C. Hypertensive Disorders of Pregnancy. In: Kuldip Singh ed. Integrated approach to Obstetrics and Gynaecology. Singapore: World Scientific; 2016: 317-328.
  2. Chi C. Diabetes in Pregnancy. In: Kuldip Singh ed. Integrated approach to Obstetrics and Gynaecology. Singapore: World Scientific; 2016: 329-338.
  3. Chi C. Venous Thromboembolism in Pregnancy. In: Kuldip Singh ed. Integrated approach to Obstetrics and Gynaecology. Singapore: World Scientific; 2016: 375-382.
  4. Chi C, Kadir RA. Antenatal diagnosis. In: Lee CA, Kadir RA, Kouides PA, eds. Inherited bleeding disorders in women. London: Wiley-Blackwell; 2009: 99-123.
  5. Chi C, Kadir RA. Obstetric management. In: Lee CA, Kadir RA, Kouides PA, eds. Inherited bleeding disorders in women. London: Wiley-Blackwell; 2009: 124-150.
  6. Chi C, England A, Kadir RA. Analgesia and anesthesia for pregnant women with inherited bleeding disorders. In: Lee CA, Kadir RA, Kouides PA, eds. Inherited bleeding disorders in women. London: Wiley-Blackwell; 2009: 151-162.

Current Clinical Research And Epidemiology Studies in Maternal Fetal Medicine

Research Interests

Gestational Diabetes, Intrapartum Care, High Risk Pregnancy, Inherited bleeding disorders, Thrombotic disorders, National Perinatal Surveillance and Database

Reviewer for Singapore Medical Journal (Recognition Award and Certificate of Reviewing with Distinction 2015)

Chairperson Maternal Fetal Medicine Session, RCOG World Congress 2018, Singapore

Member of National Healthcare Group NHG Domain Specific Review Board (DSRB) Domain D

Research Projects and Study Roles

  1. Prediction and Pregnancy Outcomes of Gestational Diabetes Mellitus: Principal Investigator
  2. Trends and Predictors in Caesarean delivery in Singapore: a population based study: Principal Investigator
  3. Stages of Family in the Making in Singapore from Antenatal to Postnatal Period: Principal Investigator
  4. An Asian based pilot study on the Basal Microbiota Profile of healthy infants: Site – Principal Investigator
  5. Exploring the feasibility of a future smartphone intervention by describing and analyzing the barriers and constraints encountered by Type 2 Diabetes Mothers with a History of Gestational Diabetes. Co - Investigator
  6. Developmental pathways to health and disease: metabolic, neurodevelopmental and related outcomes (NMRC/TCR/012-NUHS/2014) GUSTO, S-PRESTO and the NiPPeR Trial - Co – Investigator
  7. Effects of a Web/Smartphone-based Lifestyle Coaching Program on Gestational Weight Gain in Pregnant Women with Gestational Diabetes (SMART-GDM): Co – Investigator
  8. Primary prevention of Type 2 diabetes: A Randomized Controlled Trial with Interactive SmartPhone App to Restore Optimal Weight (SPAROW) in Women with Recent Gestational Diabetes: Co – Investigator
  9. Oral health, oral microbiome and salivomics in pregnant and post-partum Chinese women in Singapore: A pilot prospective cohort study: Co – Investigator
  10. A phase III, randomized, double-blind, active, controlled, multinational, multicentre, noninferiority trial using Carbetocin room temperature stable (RTS) for the prevention of postpartum haemorrhage during the third stage of labour in women delivering vaginally: Co – Investigator
  11. MFSD2A in transplacental DHA supply to the fetus and neurocognition in gestational diabetes: Co – Investigator
  12. Epidemiology of birth anthropometry among 3 major ethnic groups of Singapore infants over a 20-year period. Co – Investigator
  13. Survey on knowledge and behaviors of mothers with chronic hepatitis B on anti-viral therapy: Co – Investigator
  14. Development and evaluation of eHELP for overweight and obese pregnant women in improving pregnancy outcomes: Development phase: Collaborator

National And International Research Collaborations

  1. Trends and Determinants of Caesarean Section Births in Singapore. Collaborative Perinatal Surveillance and Research Project. Department of Obstetrics & Gynaecology, NUS School of Medicine; Department of Epidemiology, NUS School of Public Health; and Singapore Ministry of Health (ongoing)
  2. Comparing Inter-Hospital Differences in Registration Classification of Extremely Preterm Fetuses and Infants Near the Threshold of Viability. Collaborative Perinatal Surveillance and Research Project. Department of Obstetrics & Gynaecology, NUS School of Medicine; Department of Epidemiology, NUS School of Public Health; and Singapore Ministry of Health (ongoing)
  3. An Asian based pilot study on the Basal Microbiota Profile of healthy infants. NUS Yong Loo Lin School of Medicine, Department of Microbiology and Immunology. Department of Obstetrics & Gynecology, National University Hospital (ongoing).
  4. Oral health, oral microbiome and salivomics in pregnant and post-partum Chinese women in Singapore. NUS Faculty of Dentistry and Department of Obstetrics & Gynecology, NUS School of Medicine and National University Hospital (ongoing).
  5. Stages of Family in the Making in Singapore from Antenatal to Postnatal Period. Department of Psychology, Faculty of Arts and Social Science NUS, Center for Family and Population Research , Department of Obstetrics & Gynecology, NUS School of Medicine and National University Hospital (ongoing).
  6. International Registry of Mirena IUS in the management of heavy menstrual bleeding in women with inherited bleeding disorders. Lead for this Registry as Co-Chair of the SSC Scientific Subcommittee on Women’s Health Issues at the International Society of Thrombosis and Haemostasis (2014)
  7. Non-invasive prenatal diagnosis of haemophilia through analysis of free fetal DNA in maternal circulation. Royal Free Haemophilia and Thrombosis Unit in collaboration with the Department of Chemical Pathology at The Chinese University of Hong Kong (2010-2012)
  8. Activity of plasma thrombin activatable fibrinolysis inhibitor (TAFI) in pregnancy affected by preeclampsia and/or intrauterine fetal growth retardation. (2008-2012) Lead centre: Royal Free Hospital in collaboration with Colchester General Hospital, UK.
  9. Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial (MACS Trial): Murphy KE, Hannah ME, Willan AR et al; Local coordinator for the MACS Collaborative Group. Findings published as: Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet.2008 Dec 20; 372(9656): 2143-51.

Oral Presentations At National And International Conferences

  1. Li S, Lin ZJ, Wnag DD, Tan D, Biswas A, Chi C. Prevalence of Gestational Diabetes in a Multiethnic Asian Cohort. RCOG World Congress 2015, Brisbane, Australia, April 2015.
  2. Li S, Chan YH, Lim MY, Biswas A, Chi C. Caesarean sections in elective and medically indicated induction of labour at term in an Asian Cohort. The 23rd European Congress of O&G, Glasgow, UK, May 2014.
  3. Chi C, Kyei-Mensah A. Maternal Diagnostic Challenge – Diagnosis of Maternal Systemic Lupus Erythematosus from Neonatal Lupus. The London Maternal Medicine Group Meeting, May 2011 and at the Medical Grand Round, Whittington Hospital, April 2011.
  4. Chi C. Obstetric analgesia/anaesthesia in women with inherited bleeding disorders. North East Thames Trainees Presentation Meeting. Royal Free Hospital, London, November 2009.
  5. Chi C. Free fetal DNA and the prenatal diagnosis of haemophilia. North East Thames Association of Obstetricians and Gynaecologists. Royal Free Hospital, London, June 2007.
  6. Chi C, Riddell A, Griffioen A, Tuddenham EG, Kadir RA. Bleeding score as a screening tool for the identification and assessment of von Willebrand disease in women. The 2nd International Symposium on Women’s Health Issues in Thrombosis and Haemostasis, Vienna, February 2007.
  7. Chi C, Hingorani J, Paintsil J, Lee CA, England A, Kadir RA. Intrapartum Pain Relief in Women with Inherited Bleeding Disorders. XXVII International Congress of the World Federation of Hemophilia, Vancouver, May 2006.
  8. Chi C, Shiltagh N, Khan A, Pollard D, Lee CA, Kadir RA. The obstetric experience of carriers of haemophilia. British Society of Haematology Obstetric Haematology Group, London, November 2005.
  9. Chi C, Hyett JA, Finning KM, Lee CA, Kadir RA. Non-invasive fetal sex determination in early pregnancy: A new approach in the prenatal diagnosis of haemophilia. 6th International Scientific Meeting of RCOG, Cairo, Egypt, September 2005.
  10. Chi C, Hyett JA, Finning KM, Lee CA, Kadir RA. Non-invasive first trimester determination of fetal gender in pregnancy at risk of haemophilia. SpROG Cambridge, June 2005.

Poster Presentations At National And International Conferences

  1. Hong EYT, Ho-Lim S, Chi C. Impact of introducing the IADPSG 2010 recommendations for the screening and diagnosis of gestational diabetes: an institutional experience. RCOG World Congress 2018, Singapore, March 2018.
  2. Loy SL, Cheung YB, Chong YS, Gluckman P, Shek LPC, Yap F, Lee YS, Chan SY, Chi C, Chan JKY. Factors associated with time to pregnancy: a prospective cohort study of multi-ethnic Asian women. RCOG World Congress 2018, Singapore, March 2018.
  3. Ching SY, Ho-Lim S, Yew TW, Chi C. Uptake of postnatal oral glucose tolerance test in women who had gestational diabetes and strategies to improve compliance. RCOG World Congress 2018, Singapore, March 2018.
  4. Wong J, Chi C, Biswas A. Role of conservative management of a large placental chorioangioma – a case report. RCOG World Congress 2018, Singapore, March 2018.
  5. Kanneganti A, Chi C, Lim MY. The Robson’s 10: Four years of auditing caesarean sections at the National University Hospital. RCOG World Congress 2018, Singapore, March 2018.
  6. Kanneganti A, Chi C, Lim MY. The holiday season and its effects on birth rates at a busy delivery suite. RCOG World Congress 2018, Singapore, March 2018.
  7. Chua YA, Chan YH, Chua J, Tan EK, Biswas A, Chong YS, Chi C. Development of a Prediction Model for Vaginal Birth After Caesarean Section in a multiracial Asian Cohort. RCOG World Congress 2015, Brisbane, Australia, April 2015.
  8. Li S, Chan YH, Lim MY, Biswas A, Chi C. Caesarean Section Rates following Elective Induction of Labour and Expectant Management at Term in an Asian cohort. RCOG World Congress 2015, Brisbane, Australia, April 2015.
  9. Lim LM, Ching SY, Lim MY, Biswas A, Chi C. Analysis of Trends in caesarean section by the Robson Ten Group Classification. RCOG World Congress 2015, Brisbane, Australia, April 2015.
  10. Lim MY, Chi C. Improving Medical Education and Quality of Care through an Electronic Database for Delivery Outcomes. RCOG World Congress 2015, Brisbane, Australia, April 2015.
  11. Tan EK, Chi C, Lim MY, Ng B, Siau C. Human factors training in obstetric drills – is it crucial? RCOG World Congress 2015, Brisbane, Australia, April 2015.
  12. Dashraath P, Chi C, Tan EK, Biswas A. Maternal Sepsis – Have you considered Dengue? RCOG World Congress 2015, Brisbane, Australia, April 2015.
  13. Chua J, Chua YD, Chong YS, Biswas A, Chi C. Demographic and obstetric variables associated with a successful vaginal birth after one caesarean section: a study in a multi-racial Asian population. 10th Asia Pacific Congress in Maternal Fetal Medicine, Singapore, August 2014.
  14. Koh ZN, Lin ZJ, Li S, Biswas A, Chi C. Stillbirth characteristics among a multiracial Asian cohort. 10th Asia Pacific Congress in Maternal Fetal Medicine, Singapore, August 2014.
  15. Chi C, Baithun M, Kadir RA, Elsheikh S, Yee TT, Freeman-Wang T. Ligneous cervicitis/endometritis: A gynaecological presentation of plasminogen deficiency. British Society of Colposcopy and Cervical Pathology, Glasgow, April 2012.
  16. Huq FY, Chi C, Riddell A, Whitlow B, Kadir RA. Thrombin activatable fibrinolysis inhibitor (TAFI) antigen and activity levels in normal pregnancy. The 4th International Symposium on Women’s Health Issues in Thrombosis and Haemostasis, Berlin, February 2011.
  17. Myers B, Chi C, Hill M, Kadir RA, Pavord S. Obstetric complications in women with factor XI deficiency. The 4th International Symposium on Women’s Health Issues in Thrombosis and Haemostasis, Berlin, February 2011.
  18. Chi C, Pollard D, Tuddenham E, Kadir RA. Menorrhagia in adolescents with inherited bleeding disorders. The 3rd International Symposium on Women’s Health Issues in Thrombosis and Haemostasis, Prague, February 2009.
  19. Lee CA, Chi C, Shiltagh N, Pollard D, Griffeon A, Dunn N, Kadir RA. A Multidisciplinary clinic for women with inherited bleeding disorders. XXIst Congress of the International Society on Thrombosis and Haemostasis, Geneva, July 2007.
  20. Chi C, Shiltagh N, Chase A, Griffioen A, Kadir RA. The use of levonorgestrel-releasing intrauterine system in women with inherited bleeding disorders. The British International Congress of Obstetrics and Gynaecology, London, July 2007.
  21. Chi C, Bapir M, Shiltagh N, Lee CA and Kadir RA. Postpartum bleeding/lochial loss in women with inherited bleeding disorders. SpROGs, Cardiff, May 2007. (Winner of Best Poster )
  22. Chi C, Shiltagh N, Chase A, Griffioen A, Kadir RA. Long term efficacy of levonorgestrel-releasing intrauterine system in the treatment of menorrhagia in women with inherited bleeding disorders. SpROGs, Cardiff, May 2007.
  23. Chi C, Bapir M, Shiltagh N, Lee CA and Kadir RA. Assessment of puerperial blood loss (lochia) in women with inherited bleeding disorders. The 2nd International Symposium on Women’s Health Issues in Thrombosis and Haemostasis, Vienna, February 2007.
  24. Chi C, Shiltagh N, Chase A, Griffioen A, Kadir RA. Levonorgestrel-releasing intrauterine system for the management of menorrhagia in women with inherited bleeding disorders: Long term follow-up. The 2nd International Symposium on Women’s Health Issues in Thrombosis and Haemostasis, Vienna, February 2007.
  25. Chi C, Kulkarni A, Lee CA, Kadir RA. Pregnancy in women with factor XI deficiency. XXVII International Congress of the World Federation of Hemophilia, Vancouver, May 2006.
  26. Chi C, Kulkarni A, Lee CA, Kadir RA. The obstetric experience of women with factor XI deficiency. British Maternal and Fetal Medicine Society 11th Annual Conference, Cardiff, April 2006.
  27. Chi C, Hingorani J, Paintsil J, Lee CA, England A, Kadir RA. Intrapartum pain relief in women with inherited bleeding disorders. British Maternal and Fetal Medicine Society 11th Annual Conference, Cardiff, April 2006.
  28. Chi C, Shiltagh N, Khan A, Pollard D, Lee CA, Kadir RA. The obstetric experience of carriers of haemophilia. International Society on Thrombosis and Haemostasis XXth Congress, Sydney, August 2005.
  29. Chi C, Shiltagh N, Kingman CEC, Economides DL, Lee CA, Kadir RA. Identification and management of women with inherited bleeding disorder: A survey of obstetrician and gynaecologists in the United Kingdom. 6th International Scientific Meeting of RCOG, Cairo, Egypt, September 2005.
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